ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ZAK

Alias:

AZK|MLK7|MLT|MLTK|MRK|mlklak

Organism:

Homo sapiens (Human)

Chromosome:

2

Genetic Location:

2q24.2

Physical Location:

173648810-173840982 on NC_000002.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

ZAK

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_016653.2	NP_057737.2	NC_000002.10 range: 173648810..173840982
NM_133646.2	NP_598407.1	NC_000002.10 range: 173648810..173840982

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	IEA
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IDA (11836244)
GO:0004709	MAP kinase kinase kinase activity	Molecular Function	IDA (11836244)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA (11836244)
GO:0000287	magnesium ion binding	Molecular Function	IDA (11836244)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0042802	identical protein binding	Molecular Function	IPI (10924358)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0009314	response to radiation	Biological Process	IDA (11836244)
GO:0008283	cell proliferation	Biological Process	NAS (11836244)
GO:0000075	cell cycle checkpoint	Biological Process	IDA (15342622)
GO:0030154	cell differentiation	Biological Process	NAS (11836244)
GO:0008219	cell death	Biological Process	NAS (11836244)
GO:0007257	activation of JNK activity	Biological Process	IDA (11836244)
GO:0007243	protein kinase cascade	Biological Process	IDA (11836244)
GO:0007050	cell cycle arrest	Biological Process	IMP (11836244)
GO:0007049	cell cycle	Biological Process	IEA
GO:0006950	response to stress	Biological Process	NAS (11836244)
GO:0000186	activation of MAPKK activity	Biological Process	TAS (11836244)
GO:0000077	DNA damage checkpoint	Biological Process	IMP (11836244)
GO:0043065	positive regulation of apoptosis	Biological Process	IDA (10924358)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000091436

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: