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Gene Information
Gene ID:51788
Full Name:H2A histone family, member Z
Organism:Mus musculus (Mouse)
Genetic Location:3 G3
Physical Location:137527562-137529885 on NC_000069.5
Gene Type:protein-coding
Human Ortholog:GeneID: 3015    Symbol (Name): H2AFZ (H2A histone family, member Z)
Ortholog Status:The human GeneID 3015 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:H2afz
Dataset Information
Tissue:Whole brain
Phenotype:Alcohol preference
Publication:Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (|d|) and lowest Q values.
Gene Information
Original ID1:H2afz
Fold Change:1.7
Note:Significantly regulated by ethanol in cortical neurons
Dataset Information
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_016750.2NP_058030.1NC_000069.5 range: 137527562..137529885
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000786nucleosomeCellular ComponentRCA (16141072)
GO:0001740Barr bodyCellular ComponentISS (11331621)
GO:0005634nucleusCellular ComponentIDA (10716735)
GO:0005634nucleusCellular ComponentISS (11331621)
GO:0005694chromosomeCellular ComponentIEA
GO:0003677DNA bindingMolecular FunctionRCA (16141072)
GO:0006334nucleosome assemblyBiological ProcessRCA (16141072)
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0051276chromosome organization and biogenesisBiological ProcessRCA (16141072)
Other Database Cross Links
NCBI Entrez Gene:51788