ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TUBA8

Full Name:

tubulin, alpha 8

Alias:

TUBAL2

Organism:

Homo sapiens (Human)

Chromosome:

22

Genetic Location:

22q11.1

Physical Location:

16973558-16994497 on NC_000022.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D22S420

2.04

0.0011

16239281

D22S1638

2.05

0.0011

17375064

Region:		16239281-17375064
Phenotype:		TOLMX (tolerance/maximum drinking)
Name:		17067344
Method:		Linkage
Publication:		Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
Summary:		A 4-cM dense whole-genome linkage study was conducted in the Irish Affected Sib Pair Study of Alcohol Dependence. Probands, affected siblings, and parents were evaluated by structured interview. Variance component linkage analysis was applied to data from 485 families for 5 measures: initial sensitivity and tolerance (based on scales from the self-report of the effects of ethanol; maximum drinks within 24 hours, an empirically derived factor score based on withdrawal symptoms, and age at onset of alcohol dependence.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_018943.1	NP_061816.1	NC_000022.9 range: 16973558..16994497

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005856	cytoskeleton	Cellular Component	NR
GO:0005874	microtubule	Cellular Component	IEA
GO:0043234	protein complex	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0003924	GTPase activity	Molecular Function	IEA
GO:0005198	structural molecule activity	Molecular Function	IEA
GO:0005525	GTP binding	Molecular Function	IEA
GO:0007018	microtubule-based movement	Biological Process	IEA
GO:0051258	protein polymerization	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000183785

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: