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Gene Information
Gene ID:52163
Full Name:calcium/calmodulin-dependent protein kinase I
Organism:Mus musculus (Mouse)
Genetic Location:6 E3|6 48.7 cM
Physical Location:113284117-113293915 on NC_000072.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 8536    Symbol (Name): CAMK1 (calcium/calmodulin-dependent protein kinase I)
Ortholog Status:The human GeneID 8536 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Camk1
Fold Change:1.35
Note:Significantly regulated by ethanol in cortical neurons
Gene Information
Original ID1:Camk1
Fold Change:0.74
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_133926.2NP_598687.1NC_000072.5 range: 113284117..113293915, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005954calcium- and calmodulin-dependent protein kinase complexCellular ComponentTAS (11264466)
GO:0005634nucleusCellular ComponentIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0016301kinase activityMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005516calmodulin bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (15284227)
GO:0004683calmodulin-dependent protein kinase activityMolecular FunctionIEA
GO:0004674protein serine/threonine kinase activityMolecular FunctionIEA
GO:0003824catalytic activityMolecular FunctionIEA
GO:0004672protein kinase activityMolecular FunctionIEA
GO:0007399nervous system developmentBiological ProcessIEA
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0007165signal transductionBiological ProcessIDA (12130539)
GO:0006913nucleocytoplasmic transportBiological ProcessIDA (12130539)
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0030154cell differentiationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:52163