ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Sec61a1

Full Name:

Sec61 alpha 1 subunit (S. cerevisiae)

Alias:

AA408394|AA410007|Sec61a

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

6 D1

Physical Location:

88453600-88468793 on NC_000072.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 29927 Symbol (Name): SEC61A1 (Sec61 alpha 1 subunit (S. cerevisiae))

Ortholog Status:

The human GeneID 29927 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

Sec61a1

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_016906.4	NP_058602.1	NC_000072.5 range: 88453600..88468793, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	Molecular Function	IEA
GO:0006810	transport	Biological Process	IEA
GO:0009306	protein secretion	Biological Process	IEA
GO:0015031	protein transport	Biological Process	IEA
GO:0065002	intracellular protein transport across a membrane	Biological Process	IEA