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Gene Information
Gene ID:539
Full Name:ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein)
Organism:Homo sapiens (Human)
Genetic Location:21q22.1-q22.2|21q22.11
Physical Location:34197626-34210027 on NC_000021.7, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:X83218
Fold Change:1.5, 1.5
Note:Differential expression on the oligonucleotide array (two fold changes are from two case groups)
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001697.2NP_001688.1NC_000021.7 range: 34197626..34210027, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016469proton-transporting two-sector ATPase complexCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentIDA (17851741)
GO:0005759mitochondrial matrixCellular ComponentIEA
GO:0005753mitochondrial proton-transporting ATP synthase complexCellular ComponentNAS (7490082)
GO:0005753mitochondrial proton-transporting ATP synthase complexCellular ComponentIDA (12110673)
GO:0005739mitochondrionCellular ComponentIDA (12110673|17851741)
GO:0046933hydrogen ion transporting ATP synthase activity, rotational mechanismMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0016887ATPase activityMolecular FunctionIDA (12110673)
GO:0005215transporter activityMolecular FunctionNAS (7490082)
GO:0008144drug bindingMolecular FunctionIDA (15850986)
GO:0046961hydrogen ion transporting ATPase activity, rotational mechanismMolecular FunctionIEA
GO:0015992proton transportBiological ProcessNAS (17851741)
GO:0015986ATP synthesis coupled proton transportBiological ProcessIEA
GO:0042776mitochondrial ATP synthesis coupled proton transportBiological ProcessIMP (15850986)
GO:0006811ion transportBiological ProcessIEA
GO:0006200ATP catabolic processBiological ProcessIDA (12110673)
Other Database Cross Links
NCBI Entrez Gene:539
HuGE Navigator:539