ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ATP5O

Full Name:

ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein)

Alias:

ATPO|OSCP

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

21q22.1-q22.2|21q22.11

Physical Location:

34197626-34210027 on NC_000021.7, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		X83218
Fold Change:		1.5, 1.5
Note:		Differential expression on the oligonucleotide array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001697.2	NP_001688.1	NC_000021.7 range: 34197626..34210027, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016469	proton-transporting two-sector ATPase complex	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IDA (17851741)
GO:0005759	mitochondrial matrix	Cellular Component	IEA
GO:0005753	mitochondrial proton-transporting ATP synthase complex	Cellular Component	NAS (7490082)
GO:0005753	mitochondrial proton-transporting ATP synthase complex	Cellular Component	IDA (12110673)
GO:0005739	mitochondrion	Cellular Component	IDA (12110673\|17851741)
GO:0046933	hydrogen ion transporting ATP synthase activity, rotational mechanism	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0016887	ATPase activity	Molecular Function	IDA (12110673)
GO:0005215	transporter activity	Molecular Function	NAS (7490082)
GO:0008144	drug binding	Molecular Function	IDA (15850986)
GO:0046961	hydrogen ion transporting ATPase activity, rotational mechanism	Molecular Function	IEA
GO:0015992	proton transport	Biological Process	NAS (17851741)
GO:0015986	ATP synthesis coupled proton transport	Biological Process	IEA
GO:0042776	mitochondrial ATP synthesis coupled proton transport	Biological Process	IMP (15850986)
GO:0006811	ion transport	Biological Process	IEA
GO:0006200	ATP catabolic process	Biological Process	IDA (12110673)