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Gene Information
Gene ID:53972
Symbol:Ngef
Full Name:neuronal guanine nucleotide exchange factor
Alias:Tims2|ephexin
Organism:Mus musculus (Mouse)
Chromosome:1
Genetic Location:1 D|1 54.0 cM
Physical Location:89373408-89406920 on NC_000067.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 25791    Symbol (Name): NGEF (neuronal guanine nucleotide exchange factor)
Ortholog Status:The human GeneID 25791 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Ngef
Dataset Information
Name:16618939
Method:Microarray
Tissue:Whole brain
Phenotype:Alcohol preference
Publication:Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (|d|) and lowest Q values.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Ap1qAlcohol Preference Drinking17645-95 (cM)4.5 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_019867.2NP_063920.2NC_000067.5 range: 89373408..89406920, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0042995cell projectionCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005622intracellularCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0005085guanyl-nucleotide exchange factor activityMolecular FunctionIEA
GO:0005089Rho guanyl-nucleotide exchange factor activityMolecular FunctionIEA
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0007242intracellular signaling cascadeBiological ProcessIEA
GO:0009987cellular processBiological ProcessIDA (10777665)
GO:0030154cell differentiationBiological ProcessIEA
GO:0035023regulation of Rho protein signal transductionBiological ProcessIEA
GO:0007399nervous system developmentBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:53972
MGI:
Ensembl:ENSMUSG00000026259
dbSNP:Ngef
AceView:Ngef