ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ngef

Full Name:

neuronal guanine nucleotide exchange factor

Alias:

Tims2|ephexin

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 D|1 54.0 cM

Physical Location:

89373408-89406920 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 25791 Symbol (Name): NGEF (neuronal guanine nucleotide exchange factor)

Ortholog Status:

The human GeneID 25791 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

Ngef

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap1q	Alcohol Preference Drinking	1	76	45-95 (cM)	4.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019867.2	NP_063920.2	NC_000067.5 range: 89373408..89406920, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0042995	cell projection	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005085	guanyl-nucleotide exchange factor activity	Molecular Function	IEA
GO:0005089	Rho guanyl-nucleotide exchange factor activity	Molecular Function	IEA
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007242	intracellular signaling cascade	Biological Process	IEA
GO:0009987	cellular process	Biological Process	IDA (10777665)
GO:0030154	cell differentiation	Biological Process	IEA
GO:0035023	regulation of Rho protein signal transduction	Biological Process	IEA
GO:0007399	nervous system development	Biological Process	IEA