ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

POLA1

Full Name:

polymerase (DNA directed), alpha 1

Alias:

DKFZp686K1672|POLA

Organism:

Homo sapiens (Human)

Chromosome:

X

Genetic Location:

Xp22.1-p21.3

Physical Location:

24621976-24925023 on NC_000023.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

POLA1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_016937.2	NP_058633.2	NC_000023.9 range: 24621976..24925023

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005654	nucleoplasm	Cellular Component	IDA (7045121)
GO:0005635	nuclear envelope	Cellular Component	IDA (9518481)
GO:0005654	nucleoplasm	Cellular Component	EXP (6693436\|9822671\|11473323)
GO:0005658	alpha DNA polymerase:primase complex	Cellular Component	IDA (2175912)
GO:0005658	alpha DNA polymerase:primase complex	Cellular Component	TAS (2243771)
GO:0005730	nucleolus	Cellular Component	IDA (9518481)
GO:0000785	chromatin	Cellular Component	IDA (9815285)
GO:0016363	nuclear matrix	Cellular Component	IDA (1903085)
GO:0005634	nucleus	Cellular Component	IDA (4084590\|16762037)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016779	nucleotidyltransferase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (1311258\|2243771\|9395244\|9518481\|10518787\|10869558\|16438930)
GO:0000166	nucleotide binding	Molecular Function	IDA (3139084)
GO:0003677	DNA binding	Molecular Function	NAS (3359994)
GO:0003682	chromatin binding	Molecular Function	IDA (16762037)
GO:0003887	DNA-directed DNA polymerase activity	Molecular Function	IDA (893425\|3359994)
GO:0003887	DNA-directed DNA polymerase activity	Molecular Function	IMP (4084590)
GO:0003896	DNA primase activity	Molecular Function	IDA (2175912)
GO:0003677	DNA binding	Molecular Function	IDA (16762037)
GO:0000731	DNA synthesis during DNA repair	Biological Process	IDA (3335506)
GO:0000731	DNA synthesis during DNA repair	Biological Process	IMP (1508673\|1730053)
GO:0008283	cell proliferation	Biological Process	IDA (3359994)
GO:0006303	double-strand break repair via nonhomologous end joining	Biological Process	IMP (11470886)
GO:0006273	lagging strand elongation	Biological Process	IDA (2175912\|7910375)
GO:0006272	leading strand elongation	Biological Process	IDA (2175912\|7910375)
GO:0006270	DNA replication initiation	Biological Process	IDA (2175912)
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	Biological Process	IEA
GO:0000084	S phase of mitotic cell cycle	Biological Process	IDA (16762037)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000101868

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: