ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

POLD2

Full Name:

polymerase (DNA directed), delta 2, regulatory subunit 50kDa

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

7p13

Physical Location:

44120811-44129654 on NC_000007.12, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006230.2	NP_006221.1	NC_000007.12 range: 44120811..44129654, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	TAS (8530069)
GO:0005654	nucleoplasm	Cellular Component	EXP (10559261\|11473323)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0003887	DNA-directed DNA polymerase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15670210)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016779	nucleotidyltransferase activity	Molecular Function	IEA
GO:0006260	DNA replication	Biological Process	TAS (8530069)
GO:0006297	nucleotide-excision repair, DNA gap filling	Biological Process	EXP (9111189)