ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

POLE

Full Name:

polymerase (DNA directed), epsilon

Alias:

DKFZp434F222|FLJ21434|POLE1

Organism:

Homo sapiens (Human)

Chromosome:

12

Genetic Location:

12q24.3

Physical Location:

131710420-131774017 on NC_000012.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

POLE

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006231.2	NP_006222.2	NC_000012.10 range: 131710420..131774017, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (16762037)
GO:0005654	nucleoplasm	Cellular Component	EXP (6693436\|12045100)
GO:0016779	nucleotidyltransferase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (14667819)
GO:0003887	DNA-directed DNA polymerase activity	Molecular Function	IMP (16762037)
GO:0003887	DNA-directed DNA polymerase activity	Molecular Function	IEA
GO:0003682	chromatin binding	Molecular Function	IDA (16762037)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	IDA (16762037)
GO:0000731	DNA synthesis during DNA repair	Biological Process	IMP (1730053)
GO:0006297	nucleotide-excision repair, DNA gap filling	Biological Process	EXP (9111189)
GO:0006260	DNA replication	Biological Process	IEA
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	Biological Process	IEA
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	IMP (16762037)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000177084

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: