ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Atf7ip

Full Name:

activating transcription factor 7 interacting protein

Alias:

2610204M12Rik|AM|Mcaf1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

6 G1

Physical Location:

136467371-136555899 on NC_000072.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 55729 Symbol (Name): ATF7IP (activating transcription factor 7 interacting protein)

Ortholog Status:

The human GeneID 55729 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Atf7ip
Fold Change:		0.68
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019426.2	NP_062299.2	NC_000072.5 range: 136467371..136555899

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005667	transcription factor complex	Cellular Component	IDA (10777215)
GO:0003714	transcription corepressor activity	Molecular Function	IDA (10777215)
GO:0016887	ATPase activity	Molecular Function	IDA (10777215)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (10777215)
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA