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Gene Information
Gene ID:54343
Full Name:activating transcription factor 7 interacting protein
Organism:Mus musculus (Mouse)
Genetic Location:6 G1
Physical Location:136467371-136555899 on NC_000072.5
Gene Type:protein-coding
Human Ortholog:GeneID: 55729    Symbol (Name): ATF7IP (activating transcription factor 7 interacting protein)
Ortholog Status:The human GeneID 55729 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Atf7ip
Fold Change:0.68
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_019426.2NP_062299.2NC_000072.5 range: 136467371..136555899
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005667transcription factor complexCellular ComponentIDA (10777215)
GO:0003714transcription corepressor activityMolecular FunctionIDA (10777215)
GO:0016887ATPase activityMolecular FunctionIDA (10777215)
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (10777215)
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:54343