ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

5468

Symbol:

PPARG

Full Name:

peroxisome proliferator-activated receptor gamma

Alias:

NR1C3|PPARG1|PPARG2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

3p25

Physical Location:

12304348-12450854 on NC_000003.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

PPARG

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

Original ID	No. of Publications	Phenotype
PPARG	2	Alcoholism
PPARG	1	Alcohol-Related Disorders

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005037.5	NP_005028.4	NC_000003.10 range: 12304348..12450854
NM_015869.4	NP_056953.2	NC_000003.10 range: 12304348..12450854
NM_138711.3	NP_619725.2	NC_000003.10 range: 12304348..12450854
NM_138712.3	NP_619726.2	NC_000003.10 range: 12304348..12450854

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0033613	transcription activator binding	Molecular Function	IDA (10622252)
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0046965	retinoid X receptor binding	Molecular Function	IDA (9568715)
GO:0046965	retinoid X receptor binding	Molecular Function	TAS (10622252)
GO:0046982	protein heterodimerization activity	Molecular Function	TAS (9744270)
GO:0050544	arachidonic acid binding	Molecular Function	ISS (9568715)
GO:0008144	drug binding	Molecular Function	IDA (9113987\|10622252)
GO:0004955	prostaglandin receptor activity	Molecular Function	TAS (9568715)
GO:0005504	fatty acid binding	Molecular Function	TAS (9113987)
GO:0004879	ligand-dependent nuclear receptor activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0003707	steroid hormone receptor activity	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	TAS (10622252)
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (9568715)
GO:0050872	white fat cell differentiation	Biological Process	TAS (12588810)
GO:0045600	positive regulation of fat cell differentiation	Biological Process	ISS
GO:0006629	lipid metabolic process	Biological Process	TAS (9568716)
GO:0042593	glucose homeostasis	Biological Process	IMP (10622252)
GO:0007165	signal transduction	Biological Process	TAS (9568716)
GO:0007584	response to nutrient	Biological Process	TAS (10973253)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0008217	regulation of blood pressure	Biological Process	IMP (10622252)
GO:0006350	transcription	Biological Process	IEA
GO:0030224	monocyte differentiation	Biological Process	TAS (9568715)
GO:0032869	cellular response to insulin stimulus	Biological Process	IMP (10622252)
GO:0033993	response to lipid	Biological Process	ISS (9568715)
GO:0055088	lipid homeostasis	Biological Process	TAS (9113987)