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Gene Information
Gene ID:54698
Symbol:Crtam
Full Name:cytotoxic and regulatory T cell molecule
Alias:MGC141606|MGC141607
Organism:Mus musculus (Mouse)
Chromosome:9
Genetic Location:9 A5.1|9 20.5 cM
Physical Location:40780880-40812668 on NC_000075.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 56253    Symbol (Name): CRTAM (cytotoxic and regulatory T cell molecule)
Ortholog Status:The human GeneID 56253 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AF001104
Fold Change:4.9, 1.4, 2.0, 1.6
Note:4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2
Dataset Information
Name:15002731
Method:Microarray
Tissue:Whole brain
Phenotype:Acute ethanol response
Publication:Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Ap5qAlcohol Preference Drinking92510-35 (cM)4.8 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_019465.2NP_062338.2NC_000075.5 range: 40780880..40812668, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005887integral to plasma membraneCellular ComponentISS (10811014)
GO:0016020membraneCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentISS (15811952)
GO:0016021integral to membraneCellular ComponentRCA (12466851)
GO:0005886plasma membraneCellular ComponentIDA (15811952)
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0005102receptor bindingMolecular FunctionISS (15811952)
GO:0005102receptor bindingMolecular FunctionIPI (15811952)
GO:0050715positive regulation of cytokine secretionBiological ProcessISS (15811952)
GO:0051606detection of stimulusBiological ProcessIDA (15811952)
GO:0008037cell recognitionBiological ProcessISS (15811952)
GO:0008037cell recognitionBiological ProcessIDA (15811952)
GO:0006955immune responseBiological ProcessIEA
GO:0002355detection of tumor cellBiological ProcessIDA (15811952)
GO:0002860positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetBiological ProcessISS (15811952)
GO:0002860positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetBiological ProcessIDA (15811952)
GO:0002355detection of tumor cellBiological ProcessISS (15811952)
GO:0051606detection of stimulusBiological ProcessISS (15811952)
Other Database Cross Links
NCBI Entrez Gene:54698
MGI:
Ensembl:ENSMUSG00000032021
dbSNP:Crtam
AceView:Crtam