ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PPM2C

Full Name:

protein phosphatase 2C, magnesium-dependent, catalytic subunit

Alias:

FLJ32517|MGC119646|PDH|PDP|PDP1|PDPC

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

8q22.1

Physical Location:

94998337-95007471 on NC_000008.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_018444.2	NP_060914.2	NC_000008.9 range: 94998337..95007471

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0008287	protein serine/threonine phosphatase complex	Cellular Component	IEA
GO:0005759	mitochondrial matrix	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	ISS
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity	Molecular Function	IEA
GO:0004722	protein serine/threonine phosphatase activity	Molecular Function	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	IEA