ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PLEKHG6

Full Name:

pleckstrin homology domain containing, family G (with RhoGef domain) member 6

Alias:

FLJ10665|MGC126315|MGC126353|MGC126354|MyoGEF

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

12p13.31

Physical Location:

6289862-6307931 on NC_000012.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D12S99

5434815

Region:		3434815-7434815
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_018173.2	NP_060643.1	NC_000012.10 range: 6289862..6307931

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005089	Rho guanyl-nucleotide exchange factor activity	Molecular Function	IEA
GO:0005096	GTPase activator activity	Molecular Function	IEA
GO:0035023	regulation of Rho protein signal transduction	Biological Process	IEA