ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PPP2R4

Full Name:

protein phosphatase 2A activator, regulatory subunit 4

Alias:

MGC2184|PP2A|PR53|PTPA

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

9q34

Physical Location:

130913064-130951043 on NC_000009.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		X73478
Fold Change:		2.1, 2.5
Note:		Differential expression on the oligonucleotide array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000159	protein phosphatase type 2A complex	Cellular Component	TAS (10318862)
GO:0005625	soluble fraction	Cellular Component	TAS (8195217)
GO:0046982	protein heterodimerization activity	Molecular Function	TAS (10318862)
GO:0042803	protein homodimerization activity	Molecular Function	IDA (16916641)
GO:0019211	phosphatase activator activity	Molecular Function	IEA
GO:0016887	ATPase activity	Molecular Function	IDA (16916641)
GO:0008601	protein phosphatase type 2A regulator activity	Molecular Function	TAS (10318862)
GO:0008601	protein phosphatase type 2A regulator activity	Molecular Function	IDA (16916641)
GO:0008160	protein tyrosine phosphatase activator activity	Molecular Function	IDA (16916641)
GO:0005524	ATP binding	Molecular Function	IDA (16916641)
GO:0051721	protein phosphatase 2A binding	Molecular Function	IDA (16916641)
GO:0032515	negative regulation of phosphoprotein phosphatase activity	Biological Process	IDA (16916641)
GO:0032516	positive regulation of phosphoprotein phosphatase activity	Biological Process	IDA (16916641)
GO:0035307	positive regulation of protein amino acid dephosphorylation	Biological Process	IDA (16916641)
GO:0035308	negative regulation of protein amino acid dephosphorylation	Biological Process	IDA (16916641)