ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RHOT1

Full Name:

ras homolog gene family, member T1

Alias:

ARHT1|FLJ11040|FLJ12633|MIRO-1

Organism:

Homo sapiens (Human)

Chromosome:

17

Genetic Location:

17q11.2

Physical Location:

27493585-27576858 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S798

28313925

Region:		26313925-30313925
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001033566.1	NP_001028738.1	NC_000017.9 range: 27493585..27576858
NM_001033568.1	NP_001028740.1	NC_000017.9 range: 27493585..27576858
NM_018307.3	NP_060777.3	NC_000017.9 range: 27493585..27576858

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0019867	outer membrane	Cellular Component	IEA
GO:0031307	integral to mitochondrial outer membrane	Cellular Component	IDA (12482879)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005741	mitochondrial outer membrane	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005525	GTP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (16630562)
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0003674	molecular_function	Molecular Function	ND
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0019725	cellular homeostasis	Biological Process	IMP (12482879)
GO:0007264	small GTPase mediated signal transduction	Biological Process	IEA
GO:0006915	apoptosis	Biological Process	IMP (12482879)
GO:0047497	mitochondrion transport along microtubule	Biological Process	IMP (16630562)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000126858

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: