ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ALS2CR2

Full Name:

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q33.1

Physical Location:

202024636-202053818 on NC_000002.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 227154 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S117

195326948

Region:		195326948-216757195
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_018571.5	NP_061041.2	NC_000002.10 range: 202024636..202053818

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (14517248)
GO:0005634	nucleus	Cellular Component	IDA (14517248)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	NAS
GO:0005515	protein binding	Molecular Function	IPI (14676191)
GO:0004672	protein kinase activity	Molecular Function	IDA (14517248)
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (14517248)
GO:0006611	protein export from nucleus	Biological Process	IDA (14517248)
GO:0007049	cell cycle	Biological Process	IEA
GO:0032147	activation of protein kinase activity	Biological Process	IDA (14517248)