ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Fxyd1

Full Name:

FXYD domain-containing ion transport regulator 1

Alias:

0610012C17Rik|1110006M24Rik|PLM|PML

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

7 B1

Physical Location:

31836698-31840673 on NC_000073.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5348 Symbol (Name): FXYD1 (FXYD domain containing ion transport regulator 1 (phospholemman))

Ortholog Status:

The human GeneID 5348 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Fxyd1
Fold Change:		0.37
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation