ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PRMT8

Full Name:

protein arginine methyltransferase 8

Alias:

HRMT1L3|HRMT1L4

Organism:

Homo sapiens (Human)

Chromosome:

12

Genetic Location:

12p13.3

Physical Location:

3470685-3573399 on NC_000012.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D12S99

5434815

Region:		3434815-7434815
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019854.3	NP_062828.3	NC_000012.10 range: 3470685..3573399

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (16051612)
GO:0005886	plasma membrane	Cellular Component	IDA (16051612)
GO:0005515	protein binding	Molecular Function	IPI (16051612)
GO:0042803	protein homodimerization activity	Molecular Function	IDA (16051612)
GO:0035241	protein-arginine omega-N monomethyltransferase activity	Molecular Function	IDA (16051612)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	Molecular Function	IDA (16051612)
GO:0008469	histone-arginine N-methyltransferase activity	Molecular Function	IDA (16051612)
GO:0008168	methyltransferase activity	Molecular Function	IEA
GO:0046982	protein heterodimerization activity	Molecular Function	IDA (16051612)
GO:0016571	histone methylation	Biological Process	IDA (16051612)
GO:0018216	peptidyl-arginine methylation	Biological Process	IDA (16051612)
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	Biological Process	IDA (16051612)
GO:0043393	regulation of protein binding	Biological Process	TAS (16051612)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000111218

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: