ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Dstn

Full Name:

destrin

Alias:

2610043P17Rik|ADF|AU042046|Dsn|corn1|sid23p

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 H1|2 81.4 cM

Physical Location:

143741346-143769059 on NC_000068.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 11034 Symbol (Name): DSTN (destrin (actin depolymerizing factor))

Ortholog Status:

The human GeneID 11034 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Dstn
Fold Change:		1.58
Note:		Significantly regulated by ethanol in cortical neurons

Gene Information

Original ID1:		Dstn
Fold Change:		1.57
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore2	Alcohol-induced Loss of Righting Reflex	2		75.6-81.7 (cM)	6.6		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019771.1	NP_062745.1	NC_000068.6 range: 143741346..143769059

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IDA (15548599)
GO:0030864	cortical actin cytoskeleton	Cellular Component	IDA (15548599)
GO:0003779	actin binding	Molecular Function	IEA
GO:0000910	cytokinesis	Biological Process	IMP (15548599)
GO:0006928	cell motility	Biological Process	IMP (15548599)
GO:0030836	positive regulation of actin filament depolymerization	Biological Process	IMP (15548599)