ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PSMA6

Full Name:

proteasome (prosome, macropain) subunit, alpha type, 6

Alias:

IOTA|MGC22756|MGC2333|MGC23846|PROS27|p27K

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

14q13

Physical Location:

34831324-34856430 on NC_000014.7

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D14S70

33528945

Region:		31528945-35528945
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002791.1	NP_002782.1	NC_000014.7 range: 34831324..34856430

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005839	proteasome core complex	Cellular Component	NAS (1888762)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	IEA
GO:0005839	proteasome core complex	Cellular Component	IEA
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0003723	RNA binding	Molecular Function	NAS (7681138)
GO:0005515	protein binding	Molecular Function	IPI (15225636\|16169070)
GO:0004298	threonine endopeptidase activity	Molecular Function	IEA
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	NAS
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	EXP (11285280)
GO:0051436	negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle	Biological Process	EXP (15029244)
GO:0051437	positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle	Biological Process	EXP (12791267)