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Gene Information
Gene ID:5687
Full Name:proteasome (prosome, macropain) subunit, alpha type, 6
Organism:Homo sapiens (Human)
Genetic Location:14q13
Physical Location:34831324-34856430 on NC_000014.7
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D14S70  33528945
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002791.1NP_002782.1NC_000014.7 range: 34831324..34856430
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005839proteasome core complexCellular ComponentNAS (1888762)
GO:0005634nucleusCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0005829cytosolCellular ComponentIEA
GO:0005839proteasome core complexCellular ComponentIEA
GO:0008233peptidase activityMolecular FunctionIEA
GO:0003723RNA bindingMolecular FunctionNAS (7681138)
GO:0005515protein bindingMolecular FunctionIPI (15225636|16169070)
GO:0004298threonine endopeptidase activityMolecular FunctionIEA
GO:0006511ubiquitin-dependent protein catabolic processBiological ProcessIEA
GO:0006511ubiquitin-dependent protein catabolic processBiological ProcessNAS
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processBiological ProcessEXP (11285280)
GO:0051436negative regulation of ubiquitin-protein ligase activity during mitotic cell cycleBiological ProcessEXP (15029244)
GO:0051437positive regulation of ubiquitin-protein ligase activity during mitotic cell cycleBiological ProcessEXP (12791267)
Other Database Cross Links
NCBI Entrez Gene:5687
HuGE Navigator:5687