ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SMARCAD1

Full Name:

SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1

Alias:

DKFZp762K2015|ETL1|KIAA1122

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

4q22-q23

Physical Location:

95348216-95431465 on NC_000004.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

SMARCAD1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D4S423

2.61

0.0003

92691777

D4S427

3.53

0.00003

121646580

Region:		92691777-121646580
Phenotype:		ADSX (number of DSM-IV AD symptoms)
Name:		16534506
Method:		Linkage
Publication:		Prescott et al. Mol Psychiatry. (2006) Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. PubMed
Summary:		We conducted a genome scan in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). A 4 cM genome scan was conducted using 474 families of which most (96%) were comprised by affected sib pairs. Nonparametric and quantitative linkage analyses were conducted using DSM-IV alcohol dependence (AD) and number of DSM-IV AD symptoms (ADSX). Quantitative results indicate strong linkage for number of AD criteria to a broad region of chromosome 4, ranging from 4q22 to 4q32 (peak multipoint LOD=4.59, P=2.1 x 10(-6), at D4S1611). We got the gene list in the region between two markers D4S423 and D4S427 as markers between (included) these two markers have LOD scores >2 with P value <0.0003.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_020159.3	NP_064544.2	NC_000004.10 range: 95348216..95431465

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0016363	nuclear matrix	Cellular Component	NAS (11031099)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0004386	helicase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	NAS (11031099)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0045941	positive regulation of transcription	Biological Process	NAS (11031099)
GO:0016568	chromatin modification	Biological Process	NAS (11031099)
GO:0009117	nucleotide metabolic process	Biological Process	NAS (11031099)
GO:0000018	regulation of DNA recombination	Biological Process	IEP (11031099)
GO:0051260	protein homooligomerization	Biological Process	NAS (11031099)