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Gene Information
Gene ID:56923
Symbol:NMUR2
Full Name:neuromedin U receptor 2
Alias:FM-4|FM4|NMU-R2|NMU2R|TGR-1|TGR1
Organism:Homo sapiens (Human)
Chromosome:5
Genetic Location:5q33.1
Physical Location:151751301-151765016 on NC_000005.8, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene SNP Information
SNPAbuser/Control RatioCluster
rs10515675      dbSNP1.1622
Association Dataset
Name:16894614
Method:Association
Publication:Johnson et al. Am J Med Genet B Neuropsychiatr Genet. (2006) Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. PubMed
Summary:Association genome scanning can identify markers for the allelic variants that contribute to vulnerability to complex disorders, including alcohol dependence. To improve the power and feasibility of this approach, we report validation of 100k microarray-based allelic frequency assessments in pooled DNA samples. We then use this approach with unrelated alcohol-dependent versus control individuals sampled from pedigrees collected by the Collaborative Study on the Genetics of Alcoholism (COGA). Allele frequency differences between alcohol-dependent and control individuals are assessed in quadruplicate at 104,268 autosomal SNPs in pooled samples. One hundred eighty-eight SNPs provide (1) the largest allele frequency differences between dependent versus control individuals; (2) t values 3 for these differences; and (3) clustering, so that 51 relatively small chromosomal regions contain at least three SNPs that satisfy criteria 1 and 2 above (Monte Carlo P = 0.00034).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_020167.4NP_064552.3NC_000005.8 range: 151751301..151765016, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIDA (10899166)
GO:0001584rhodopsin-like receptor activityMolecular FunctionIEA
GO:0001607neuromedin U receptor activityMolecular FunctionIDA (10887190)
GO:0004872receptor activityMolecular FunctionIEA
GO:0005229intracellular calcium activated chloride channel activityMolecular FunctionIDA (10899166)
GO:0005525GTP bindingMolecular FunctionIDA (10899166)
GO:0007631feeding behaviorBiological ProcessTAS (10894543)
GO:0019226transmission of nerve impulseBiological ProcessIEP (10899166)
GO:0043006calcium-dependent phospholipase A2 activationBiological ProcessIDA (10899166)
GO:0048016inositol phosphate-mediated signalingBiological ProcessIDA (10899166)
GO:0007417central nervous system developmentBiological ProcessIEP (10899166)
GO:0007218neuropeptide signaling pathwayBiological ProcessTAS (10894543)
GO:0007204elevation of cytosolic calcium ion concentrationBiological ProcessIDA (10899166)
GO:0007200G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)Biological ProcessIDA (10899166)
GO:0007165signal transductionBiological ProcessIEA
GO:0006940regulation of smooth muscle contractionBiological ProcessNAS (10887190)
GO:0006816calcium ion transportBiological ProcessIDA (10899166)
GO:0050482arachidonic acid secretionBiological ProcessIDA (10887190)
Other Database Cross Links
NCBI Entrez Gene:56923
HGNC:16454
Ensembl:ENSG00000132911
MIM:605108
HPRD:12003
HuGE Navigator:56923
dbSNP:NMUR2
GeneCard:NMUR2
AceView:NMUR2