ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PSMB7

Full Name:

proteasome (prosome, macropain) subunit, beta type, 7

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

9q34.11-q34.12

Physical Location:

126155564-126217541 on NC_000009.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 19177 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		D38048
Fold Change:		-1.7, -1.4
Note:		Differential expression on the oligonucleotide array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002799.2	NP_002790.1	NC_000009.10 range: 126155564..126217541, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	IEA
GO:0005839	proteasome core complex	Cellular Component	IEA
GO:0004298	threonine endopeptidase activity	Molecular Function	IEA
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	EXP (11285280)
GO:0051436	negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle	Biological Process	EXP (15029244)
GO:0051437	positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle	Biological Process	EXP (12791267)