ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RNPEPL1

Full Name:

arginyl aminopeptidase (aminopeptidase B)-like 1

Alias:

FLJ10806|FLJ26675|MGC99544

Organism:

Homo sapiens (Human)

Chromosome:

2

Genetic Location:

2q37.3

Physical Location:

241156776-241166816 on NC_000002.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S2973

2.20

0.0007

235696080

D2S140

1.95

0.0014

241388318

Region:		235696080-241388318
Phenotype:		WDSFS (withdrawal symptoms factor score)
Name:		17067344
Method:		Linkage
Publication:		Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
Summary:		A 4-cM dense whole-genome linkage study was conducted in the Irish Affected Sib Pair Study of Alcohol Dependence. Probands, affected siblings, and parents were evaluated by structured interview. Variance component linkage analysis was applied to data from 485 families for 5 measures: initial sensitivity and tolerance (based on scales from the self-report of the effects of ethanol; maximum drinks within 24 hours, an empirically derived factor score based on withdrawal symptoms, and age at onset of alcohol dependence.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_018226.3	NP_060696.3	NC_000002.10 range: 241156776..241166816

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0004177	aminopeptidase activity	Molecular Function	IEA
GO:0004179	membrane alanyl aminopeptidase activity	Molecular Function	IEA
GO:0004428	inositol or phosphatidylinositol kinase activity	Molecular Function	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0008237	metallopeptidase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006508	proteolysis	Biological Process	IEA
GO:0019370	leukotriene biosynthetic process	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000142327

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: