ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PSMD11

Full Name:

proteasome (prosome, macropain) 26S subunit, non-ATPase, 11

Alias:

MGC3844|Rpn6|S9|p44.5

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q11.2

Physical Location:

27795614-27832154 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 69077 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S798

28313925

Region:		26313925-30313925
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002815.2	NP_002806.2	NC_000017.9 range: 27795614..27832154

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000502	proteasome complex	Cellular Component	TAS (9119060)
GO:0005829	cytosol	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	EXP (11285280)
GO:0051436	negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle	Biological Process	EXP (15029244)
GO:0051437	positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle	Biological Process	EXP (12791267)