ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PTGDS

Full Name:

prostaglandin D2 synthase 21kDa (brain)

Alias:

LPGDS|PDS|PGD2|PGDS|PGDS2

Organism:

Homo sapiens (Human)

Chromosome:

9

Genetic Location:

9q34.2-q34.3

Physical Location:

138991776-138996014 on NC_000009.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		M98539
Fold Change:		-2, -2.2
Note:		Differential expression on the oligonucleotide array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000954.5	NP_000945.3	NC_000009.10 range: 138991776..138996014

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005791	rough endoplasmic reticulum	Cellular Component	IDA (9065498)
GO:0005794	Golgi apparatus	Cellular Component	ISS
GO:0031965	nuclear membrane	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0005576	extracellular region	Cellular Component	IDA (7692978)
GO:0016020	membrane	Cellular Component	IEA
GO:0005501	retinoid binding	Molecular Function	ISS
GO:0005488	binding	Molecular Function	IEA
GO:0005215	transporter activity	Molecular Function	ISS
GO:0004667	prostaglandin-D synthase activity	Molecular Function	ISS
GO:0016853	isomerase activity	Molecular Function	IEA
GO:0006810	transport	Biological Process	ISS
GO:0006633	fatty acid biosynthetic process	Biological Process	IEA
GO:0006629	lipid metabolic process	Biological Process	IEA
GO:0001516	prostaglandin biosynthetic process	Biological Process	ISS
GO:0045187	regulation of circadian sleep/wake cycle, sleep	Biological Process	ISS

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000107317

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: