ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PTPRB

Full Name:

protein tyrosine phosphatase, receptor type, B

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

12q15-q21

Physical Location:

69196896-69317485 on NC_000012.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

PTPRB

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

Original ID	No. of Publications	Phenotype
PTPRB	1	Alcoholism

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (2170109)
GO:0016020	membrane	Cellular Component	IEA
GO:0005624	membrane fraction	Cellular Component	NR
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0004725	protein tyrosine phosphatase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12907755)
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	Molecular Function	TAS (2170109)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0016791	phosphoric monoester hydrolase activity	Molecular Function	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	TAS (2170109)