ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SNX6

Full Name:

sorting nexin 6

Alias:

MGC3157|MSTP010|TFAF2

Organism:

Homo sapiens (Human)

Chromosome:

14

Genetic Location:

14q13.2

Physical Location:

34100368-34169116 on NC_000014.7, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D14S70

33528945

Region:		31528945-35528945
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_021249.3	NP_067072.3	NC_000014.7 range: 34100368..34169116, complement
NM_152233.2	NP_689419.2	NC_000014.7 range: 34100368..34169116, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	NAS (11279102)
GO:0005737	cytoplasm	Cellular Component	IDA (11279102)
GO:0005515	protein binding	Molecular Function	IEA
GO:0035091	phosphoinositide binding	Molecular Function	IEA
GO:0042803	protein homodimerization activity	Molecular Function	IPI (11279102)
GO:0005515	protein binding	Molecular Function	IPI (11279102)
GO:0006886	intracellular protein transport	Biological Process	NAS (11279102)
GO:0007175	negative regulation of epidermal growth factor receptor activity	Biological Process	NAS (11279102)
GO:0016481	negative regulation of transcription	Biological Process	IDA (11279102)
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Biological Process	IDA (11279102)
GO:0007154	cell communication	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000129515

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: