ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RAC3

Full Name:

ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q25.3

Physical Location:

77582820-77585368 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

RAC3

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S928

77846128

Region:		75846128-78774742
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005052.2	NP_005043.1	NC_000017.9 range: 77582820..77585368

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0042995	cell projection	Cellular Component	IEA
GO:0012505	endomembrane system	Cellular Component	IDA (11956649)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	IEA
GO:0005525	GTP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (11956649)
GO:0003924	GTPase activity	Molecular Function	IDA (11956649)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0007264	small GTPase mediated signal transduction	Biological Process	IEA
GO:0030031	cell projection biogenesis	Biological Process	IDA (11956649)
GO:0030036	actin cytoskeleton organization and biogenesis	Biological Process	IDA (11956649)