ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

5888

Symbol:

RAD51

Full Name:

RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

15q15.1

Physical Location:

38774650-38811647 on NC_000015.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		N72527
Fold Change:		2.04
P Value:		0.04
Tissue:		Nucleus accumbens

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002875.3	NP_002866.2	NC_000015.8 range: 38774650..38811647
NM_133487.2	NP_597994.2	NC_000015.8 range: 38774650..38811647

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	ISS
GO:0005654	nucleoplasm	Cellular Component	EXP (9826763\|10438626\|11080452\|12606939)
GO:0005634	nucleus	Cellular Component	IDA (12442171)
GO:0000794	condensed nuclear chromosome	Cellular Component	ISS
GO:0016605	PML body	Cellular Component	IDA (11309417)
GO:0016887	ATPase activity	Molecular Function	ISS
GO:0017111	nucleoside-triphosphatase activity	Molecular Function	IEA
GO:0043142	single-stranded DNA-dependent ATPase activity	Molecular Function	IDA (7988572\|8929543)
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0008094	DNA-dependent ATPase activity	Molecular Function	IEA
GO:0042802	identical protein binding	Molecular Function	IPI (12442171)
GO:0000150	recombinase activity	Molecular Function	ISS
GO:0005524	ATP binding	Molecular Function	ISS
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0003684	damaged DNA binding	Molecular Function	IEA
GO:0003690	double-stranded DNA binding	Molecular Function	IDA (7988572)
GO:0003690	double-stranded DNA binding	Molecular Function	ISS
GO:0003697	single-stranded DNA binding	Molecular Function	IDA (7988572)
GO:0003697	single-stranded DNA binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0005524	ATP binding	Molecular Function	IEA
GO:0008022	protein C-terminus binding	Molecular Function	IPI (17515903)
GO:0051106	positive regulation of DNA ligation	Biological Process	IDA (8929543)
GO:0007131	meiotic recombination	Biological Process	TAS (8358431)
GO:0007126	meiosis	Biological Process	ISS
GO:0006312	mitotic recombination	Biological Process	TAS (8358431)
GO:0006281	DNA repair	Biological Process	TAS (8358431)
GO:0006281	DNA repair	Biological Process	IEA
GO:0006268	DNA unwinding during replication	Biological Process	ISS
GO:0006268	DNA unwinding during replication	Biological Process	IDA (7988572)
GO:0000724	double-strand break repair via homologous recombination	Biological Process	TAS (12427746)
GO:0051260	protein homooligomerization	Biological Process	IPI (12442171)