ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Rab2a

Full Name:

RAB2A, member RAS oncogene family

Alias:

9330148M11Rik|C80220|Rab2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 A1

Physical Location:

8462790-8534848 on NC_000070.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5862 Symbol (Name): RAB2A (RAB2A, member RAS oncogene family)

Ortholog Status:

The human GeneID 5862 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rab2
Fold Change:		1.59
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_021518.3	NP_067493.1	NC_000070.5 range: 8462790..8534848

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IDA (11042173)
GO:0016020	membrane	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005525	GTP binding	Molecular Function	IEA
GO:0015031	protein transport	Biological Process	IEA
GO:0007264	small GTPase mediated signal transduction	Biological Process	IEA
GO:0006886	intracellular protein transport	Biological Process	TAS (11042173)
GO:0006810	transport	Biological Process	IEA
GO:0016192	vesicle-mediated transport	Biological Process	IEA