ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Lxn

Full Name:

latexin

Alias:

MGC93322

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q31

Physical Location:

157310035-157315904 on NC_005101.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 56925 Symbol (Name): LXN (latexin)

Ortholog Status:

The human GeneID 56925 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031655.1	NP_113843.1	NC_005101.2 range: 157310035..157315904, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0004857	enzyme inhibitor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0008191	metalloendopeptidase inhibitor activity	Molecular Function	IEA
GO:0008191	metalloendopeptidase inhibitor activity	Molecular Function	ISS
GO:0050965	detection of temperature stimulus involved in sensory perception of pain	Biological Process	IEA
GO:0050965	detection of temperature stimulus involved in sensory perception of pain	Biological Process	ISS