| Gene Information |
| Gene ID: | | 59287 |
| Symbol: | | Ncstn |
| Full Name: | | nicastrin |
| Alias: | | 9430068N19Rik|AA727311|Aph2|D1Dau13e|Kiaa0253|Nct|mKIAA0253 |
| Organism: | | Mus musculus (Mouse) |
| Chromosome: | | 1 |
| Genetic Location: | | 1 H3|1 93.5 cM |
| Physical Location: | | 173996228-174012824 on NC_000067.5, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 23385 Symbol (Name): NCSTN (nicastrin) |
| Ortholog Status: | | The human GeneID 23385 is not in current human dataset. |
|
| Gene in Ethanol Study Datasets |
| QTL Information | | QTL | Phenotype | Chr | Peak (cM) | LOD | P Value | Range | Status | QTL Link | |
| Alcw1 | Acute Alcohol Withdrawal | 1 | 96 | 172.3-176.5 (Mb) | 5.6 | 3.00E-07 | Significant | PARC | | Calw1/Alcdp1 | Chronic Alcohol Withdrawal | 1 | 96 | 89-106.3 (cM) | 7.6 | 2.00E-09 | Significant | PARC | | Ap1q | Alcohol Preference Drinking | 1 | 76 | 45-95 (cM) | 4.5 | | Significant | PARC |
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| Gene Refseq Sequence Annotation |
|
| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005624 | membrane fraction | Cellular Component | IDA (11943765|15634781|15886206) | |
| GO:0005783 | endoplasmic reticulum | Cellular Component | IDA (12646573) | |
| GO:0005794 | Golgi apparatus | Cellular Component | IDA (12646573) | |
| GO:0005886 | plasma membrane | Cellular Component | IDA (12646573) | |
| GO:0016020 | membrane | Cellular Component | IEA | |
| GO:0016021 | integral to membrane | Cellular Component | IEA | |
| GO:0005515 | protein binding | Molecular Function | IPI (15474363) | |
| GO:0007219 | Notch signaling pathway | Biological Process | IEA | |
| GO:0016485 | protein processing | Biological Process | IEA | |
|
| Other Database Cross Links |
| NCBI Entrez Gene: | | 59287 |
| MGI: | |
| Ensembl: | | ENSMUSG00000003458 |
| dbSNP: | | Ncstn |
| AceView: | | Ncstn |
