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Gene Information
Gene ID:5983
Symbol:RFC3
Full Name:replication factor C (activator 1) 3, 38kDa
Alias:MGC5276|RFC38
Organism:Homo sapiens (Human)
Chromosome:13
Genetic Location:13q12.3-q13
Physical Location:33290205-33438694 on NC_000013.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D13S171  32151912
Region:32151912-40979230
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002915.3NP_002906.1NC_000013.9 range: 33290205..33438694
NM_181558.2NP_853536.2NC_000013.9 range: 33290205..33438694
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005654nucleoplasmCellular ComponentEXP (9822671)
GO:0005663DNA replication factor C complexCellular ComponentTAS (7774928)
GO:0005663DNA replication factor C complexCellular ComponentIDA (9488738)
GO:0005634nucleusCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (9488738)
GO:0003689DNA clamp loader activityMolecular FunctionTAS (9488738)
GO:0016887ATPase activityMolecular FunctionIDA (9488738)
GO:0000731DNA synthesis during DNA repairBiological ProcessTAS (9488738)
GO:0006271DNA strand elongation during DNA replicationBiological ProcessTAS (7774928)
GO:0006297nucleotide-excision repair, DNA gap fillingBiological ProcessEXP (9111189)
Other Database Cross Links
NCBI Entrez Gene:5983
HGNC:9971
Ensembl:ENSG00000133119
MIM:600405
HPRD:02676
HuGE Navigator:5983
dbSNP:RFC3
GeneCard:RFC3
AceView:RFC3