ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RGS4

Full Name:

regulator of G-protein signaling 4

Alias:

DKFZp761F1924|MGC2124|MGC60244|RGP4|SCZD9

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1q23.3

Physical Location:

161305284-161313215 on NC_000001.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 19736 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AI651602
Fold Change:		1.5, 1.8
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Information

Original ID1:

RGS4

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0005096	GTPase activator activity	Molecular Function	TAS (10747990)
GO:0005516	calmodulin binding	Molecular Function	TAS (10747990)
GO:0000188	inactivation of MAPK activity	Biological Process	TAS (8602223)
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	Biological Process	TAS (10747990)
GO:0009968	negative regulation of signal transduction	Biological Process	IEA