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Gene Information
Gene ID:5999
Full Name:regulator of G-protein signaling 4
Organism:Homo sapiens (Human)
Genetic Location:1q23.3
Physical Location:161305284-161313215 on NC_000001.9
Gene Type:protein-coding
Orthologs:This gene has Mouse: 19736 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AI651602
Fold Change:1.5, 1.8
Note:Differential Expression on the cDNA array (two fold changes are from two case groups)
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Information
Original ID1:RGS4
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001102445.2NP_001095915.1NC_000001.9 range: 161305284..161313215
NM_005613.5NP_005604.1NC_000001.9 range: 161305284..161313215
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0004871signal transducer activityMolecular FunctionIEA
GO:0005096GTPase activator activityMolecular FunctionTAS (10747990)
GO:0005516calmodulin bindingMolecular FunctionTAS (10747990)
GO:0000188inactivation of MAPK activityBiological ProcessTAS (8602223)
GO:0008277regulation of G-protein coupled receptor protein signaling pathwayBiological ProcessTAS (10747990)
GO:0009968negative regulation of signal transductionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:5999
HuGE Navigator:5999