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Gene Information
Gene ID:60
Full Name:actin, beta
Organism:Homo sapiens (Human)
Genetic Location:7p15-p12
Physical Location:5533311-5536746 on NC_000007.12, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:ACTB
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D7S517  4464441
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001101.3NP_001092.1NC_000007.12 range: 5533311..5536746, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0035267NuA4 histone acetyltransferase complexCellular ComponentIDA (10966108)
GO:0005856cytoskeletonCellular ComponentTAS (16130169)
GO:0005737cytoplasmCellular ComponentTAS (16130169)
GO:0005515protein bindingMolecular FunctionIPI (17342765)
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0005200structural constituent of cytoskeletonMolecular FunctionTAS (6202424)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0006928cell motilityBiological ProcessTAS (6202424|16130169)
GO:0007605sensory perception of soundBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:60
HuGE Navigator:60