ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Slc28a2

Full Name:

solute carrier family 28 (sodium-coupled nucleoside transporter), member 2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

3q35

Physical Location:

109350530-109372025 on NC_005102.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9153 Symbol (Name): SLC28A2 (solute carrier family 28 (sodium-coupled nucleoside transporter), member 2)

Ortholog Status:

The human GeneID 9153 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031664.1	NP_113852.1	NC_005102.2 range: 109350530..109372025, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0001882	nucleoside binding	Molecular Function	IEA
GO:0005415	nucleoside:sodium symporter activity	Molecular Function	IEA
GO:0015211	purine nucleoside transmembrane transporter activity	Molecular Function	ISS
GO:0006810	transport	Biological Process	IEA