ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

KCNK15

Full Name:

potassium channel, subfamily K, member 15

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

20q12-q13

Physical Location:

42807901-42813081 on NC_000020.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D20S119

43082264

Region:		41082264-45082264
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022358.2	NP_071753.1	NC_000020.9 range: 42807901..42813081

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005244	voltage-gated ion channel activity	Molecular Function	IDA (11749039)
GO:0005267	potassium channel activity	Molecular Function	IEA
GO:0030955	potassium ion binding	Molecular Function	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006813	potassium ion transport	Biological Process	IEA