ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RPLP0

Full Name:

ribosomal protein, large, P0

Alias:

L10E|MGC111226|MGC88175|P0|PRLP0|RPP0

Organism:

Homo sapiens (Human)

Chromosome:

12

Genetic Location:

12q24.2

Physical Location:

119118885-119123396 on NC_000012.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		M17885
Fold Change:		-1.4, -1.4
Note:		Differential expression on the oligonucleotide array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Information

Original ID1:

RPLP0

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001002.3	NP_000993.1	NC_000012.10 range: 119118885..119123396, complement
NM_053275.3	NP_444505.1	NC_000012.10 range: 119118885..119123396, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	EXP (14567916)
GO:0022625	cytosolic large ribosomal subunit	Cellular Component	TAS (3323886)
GO:0005840	ribosome	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	IEA
GO:0003723	RNA binding	Molecular Function	TAS (3323886)
GO:0005515	protein binding	Molecular Function	IPI (15303970)
GO:0003735	structural constituent of ribosome	Molecular Function	TAS (3323886)
GO:0003735	structural constituent of ribosome	Molecular Function	IEA
GO:0006414	translational elongation	Biological Process	EXP (15189156)
GO:0006414	translational elongation	Biological Process	IEA
GO:0042254	ribosome biogenesis and assembly	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000089157

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: