ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MRPL12

Full Name:

mitochondrial ribosomal protein L12

Alias:

5c5-2|L12mt|MGC8610|MRP-L31/34|MRPL7|MRPL7/L12|RPML12

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q25

Physical Location:

77280811-77284952 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S928

77846128

Region:		75846128-78774742
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002949.2	NP_002940.2	NC_000017.9 range: 77280811..77284952

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	IDA (17337445)
GO:0005840	ribosome	Cellular Component	IEA
GO:0005762	mitochondrial large ribosomal subunit	Cellular Component	TAS (8626705)
GO:0005622	intracellular	Cellular Component	IEA
GO:0003723	RNA binding	Molecular Function	TAS (8626705)
GO:0005515	protein binding	Molecular Function	IPI (17337445)
GO:0003735	structural constituent of ribosome	Molecular Function	TAS (9169145)
GO:0003735	structural constituent of ribosome	Molecular Function	IEA
GO:0006390	transcription from mitochondrial promoter	Biological Process	IDA (17337445)
GO:0006412	translation	Biological Process	IEA
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA (17337445)