ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RREB1

Full Name:

ras responsive element binding protein 1

Alias:

FINB|LZ321|RREB-1|Zep-1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

6p25

Physical Location:

7053262-7196193 on NC_000006.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D6S1574

5957132

Region:		3957132-7957132
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Marker

LOD

P value

Location (bp)

D6S309

8169921

Region:		6169921-10169921
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	TAS (9305772)
GO:0005737	cytoplasm	Cellular Component	TAS (9305772)
GO:0016607	nuclear speck	Cellular Component	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0016563	transcription activator activity	Molecular Function	TAS (9305772)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0007265	Ras protein signal transduction	Biological Process	TAS (8816445)
GO:0007275	multicellular organismal development	Biological Process	TAS (8816445)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	TAS (9305772)
GO:0006350	transcription	Biological Process	IEA
GO:0006366	transcription from RNA polymerase II promoter	Biological Process	TAS (8816445)