ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SCO1

Full Name:

SCO cytochrome oxidase deficient homolog 1 (yeast)

Alias:

SCOD1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17p12-p13

Physical Location:

10524378-10541561 on NC_000017.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 52892 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

SCO1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S1852

10456226

Region:		8456226-12456226
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004589.2	NP_004580.1	NC_000017.9 range: 10524378..10541561, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	TAS (9878253)
GO:0005743	mitochondrial inner membrane	Cellular Component	IEA
GO:0005507	copper ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006091	generation of precursor metabolites and energy	Biological Process	TAS (9878253)
GO:0006825	copper ion transport	Biological Process	IEA
GO:0006878	cellular copper ion homeostasis	Biological Process	IEA
GO:0008535	respiratory chain complex IV assembly	Biological Process	TAS (9878253)