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Gene Information
Gene ID:6354
Symbol:CCL7
Full Name:chemokine (C-C motif) ligand 7
Alias:FIC|MARC|MCP-3|MCP3|MGC138463|MGC138465|NC28|SCYA6|SCYA7
Organism:Homo sapiens (Human)
Chromosome:17
Genetic Location:17q11.2-q12
Physical Location:29621352-29623368 on NC_000017.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D17S798  28313925
Region:26313925-30313925
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_006273.2NP_006264.2NC_000017.9 range: 29621352..29623368
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentTAS (7916328)
GO:0008009chemokine activityMolecular FunctionTAS (10770925)
GO:0008009chemokine activityMolecular FunctionIEA
GO:0008201heparin bindingMolecular FunctionIEA
GO:0006954inflammatory responseBiological ProcessIEA
GO:0007165signal transductionBiological ProcessTAS (10201901|10770925)
GO:0007267cell-cell signalingBiological ProcessTAS (7916328)
GO:0006935chemotaxisBiological ProcessTAS (9780207)
GO:0006874cellular calcium ion homeostasisBiological ProcessTAS (10770925)
GO:0006955immune responseBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:6354
HGNC:10634
Ensembl:ENSG00000108688
MIM:158106
HPRD:01150
HuGE Navigator:6354
dbSNP:CCL7
GeneCard:CCL7
AceView:CCL7