ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CCL8

Full Name:

chemokine (C-C motif) ligand 8

Alias:

HC14|MCP-2|MCP2|SCYA10|SCYA8

Organism:

Homo sapiens (Human)

Chromosome:

17

Genetic Location:

17q11.2

Physical Location:

29670178-29672533 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S798

28313925

Region:		26313925-30313925
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005623.2	NP_005614.2	NC_000017.9 range: 29670178..29672533

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	IEA
GO:0008201	heparin binding	Molecular Function	IEA
GO:0008009	chemokine activity	Molecular Function	TAS (9468473)
GO:0004871	signal transducer activity	Molecular Function	TAS (9119400\|10734056)
GO:0006954	inflammatory response	Biological Process	IEA
GO:0006935	chemotaxis	Biological Process	TAS (9468473)
GO:0007165	signal transduction	Biological Process	TAS (9119400)
GO:0007267	cell-cell signaling	Biological Process	TAS (10734056)
GO:0006887	exocytosis	Biological Process	TAS (10734056)
GO:0006816	calcium ion transport	Biological Process	TAS (10734056)
GO:0009615	response to virus	Biological Process	TAS (9468473)
GO:0006955	immune response	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000108700

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: