ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

XCL1

Full Name:

chemokine (C motif) ligand 1

Alias:

ATAC|LPTN|LTN|SCM-1|SCM-1a|SCM1|SCYC1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1q23

Physical Location:

166812479-166817938 on NC_000001.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 16963 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AL031736
Fold Change:		1.8, 1.6
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002995.1	NP_002986.1	NC_000001.9 range: 166812479..166817938

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	IEA
GO:0008009	chemokine activity	Molecular Function	TAS (7602097)
GO:0006874	cellular calcium ion homeostasis	Biological Process	TAS (7602097)
GO:0006935	chemotaxis	Biological Process	TAS (7602097)
GO:0006955	immune response	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	TAS (7602097)
GO:0007267	cell-cell signaling	Biological Process	TAS (7602097)