ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CXCL12

Full Name:

chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

10q11.1

Physical Location:

44185610-44200547 on NC_000010.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Information

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	IEA
GO:0004871	signal transducer activity	Molecular Function	TAS (10491003\|10802710)
GO:0008083	growth factor activity	Molecular Function	IEA
GO:0008009	chemokine activity	Molecular Function	IEA
GO:0008009	chemokine activity	Molecular Function	TAS (10772939)
GO:0007267	cell-cell signaling	Biological Process	NR
GO:0008015	blood circulation	Biological Process	TAS (10772939)
GO:0008064	regulation of actin polymerization and/or depolymerization	Biological Process	TAS (10570282)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	TAS (8752280)
GO:0007165	signal transduction	Biological Process	TAS (10491003)
GO:0007155	cell adhesion	Biological Process	TAS (10198043)
GO:0006955	immune response	Biological Process	TAS (10802710)
GO:0006955	immune response	Biological Process	IEA
GO:0006954	inflammatory response	Biological Process	NR
GO:0006935	chemotaxis	Biological Process	TAS (10620615)
GO:0006874	cellular calcium ion homeostasis	Biological Process	TAS (10772939)
GO:0009615	response to virus	Biological Process	TAS (10772939)