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Gene Information
Gene ID:640
Symbol:BLK
Full Name:B lymphoid tyrosine kinase
Alias:MGC10442
Organism:Homo sapiens (Human)
Chromosome:8
Genetic Location:8p23-p22
Physical Location:11388929-11459516 on NC_000008.9
Gene Type:protein-coding
Orthologs:This gene has Mouse: 12143 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D8S550  10918926
Region:8918926-12918926
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001715.2NP_001706.2NC_000008.9 range: 11388929..11459516
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0004715non-membrane spanning protein tyrosine kinase activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0007243protein kinase cascadeBiological ProcessTAS (2404338)
Other Database Cross Links
NCBI Entrez Gene:640
HGNC:1057
Ensembl:ENSG00000136573
MIM:191305
HPRD:01866
HuGE Navigator:640
dbSNP:BLK
GeneCard:BLK
AceView:BLK