ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

BLK

Full Name:

B lymphoid tyrosine kinase

Alias:

MGC10442

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

8p23-p22

Physical Location:

11388929-11459516 on NC_000008.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 12143 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D8S550

10918926

Region:		8918926-12918926
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001715.2	NP_001706.2	NC_000008.9 range: 11388929..11459516

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0004715	non-membrane spanning protein tyrosine kinase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0007243	protein kinase cascade	Biological Process	TAS (2404338)