ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pmpcb

Full Name:

peptidase (mitochondrial processing) beta

Alias:

Mppb

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q11

Physical Location:

8746903-8759680 on NC_005103.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9512 Symbol (Name): PMPCB (peptidase (mitochondrial processing) beta)

Ortholog Status:

The human GeneID 9512 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022395.1	NP_071790.1	NC_005103.2 range: 8746903..8759680, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005743	mitochondrial inner membrane	Cellular Component	ISS
GO:0005739	mitochondrion	Cellular Component	IDA (8506385)
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	ISS
GO:0005743	mitochondrial inner membrane	Cellular Component	IEA
GO:0005759	mitochondrial matrix	Cellular Component	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0004240	mitochondrial processing peptidase activity	Molecular Function	IEA
GO:0004240	mitochondrial processing peptidase activity	Molecular Function	TAS (8506385)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006508	proteolysis	Biological Process	IEA
GO:0006627	mitochondrial protein processing during import	Biological Process	TAS (8506385)