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Gene Information
Gene ID:64198
Full Name:peptidase (mitochondrial processing) beta
Organism:Rattus norvegicus (Rat)
Genetic Location:4q11
Physical Location:8746903-8759680 on NC_005103.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 9512    Symbol (Name): PMPCB (peptidase (mitochondrial processing) beta)
Ortholog Status:The human GeneID 9512 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pmpcb
Fold Change:1.26
Dataset Information
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_022395.1NP_071790.1NC_005103.2 range: 8746903..8759680, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005743mitochondrial inner membraneCellular ComponentISS
GO:0005739mitochondrionCellular ComponentIDA (8506385)
GO:0005739mitochondrionCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentISS
GO:0005743mitochondrial inner membraneCellular ComponentIEA
GO:0005759mitochondrial matrixCellular ComponentIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0004240mitochondrial processing peptidase activityMolecular FunctionIEA
GO:0004240mitochondrial processing peptidase activityMolecular FunctionTAS (8506385)
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0006508proteolysisBiological ProcessIEA
GO:0006627mitochondrial protein processing during importBiological ProcessTAS (8506385)
Other Database Cross Links
NCBI Entrez Gene:64198